The best antiwrinkle creams contain proven active ingredients. Look for products with retinol or retinoids, which are the most effective ingredients for reducing wrinkles by increasing cell turnover and collagen production. Creams with peptides help signal skin to produce more collagen. Vitamin C serums brighten and protect against damage. Hyaluronic acid plumps skin with hydration. Niacinamide improves skin barrier and reduces inflammation. Alpha hydroxy acids (AHAs) gently exfoliate. The best cream for you depends on your skin type and tolerance. Start with lower concentrations and increase gradually. Prescription retinoids like tretinoin are stronger than over-the-counter options. Consistency and patience are key.